After Friday's games, the American League's postseason matchups became official.
Despite their 14-7 win over the Texas Rangers (76-84), the Yankees (103-57) lost out on home-field advantage to the Houston Astros (105-55), who clinched the AL's best record with a 4-0 victory against the Los Angeles Angels.
As a result, AL East champion New York gets AL Central champion Minnesota when the ALDS starts with Game 1 next Friday at Yankee Stadium.
The Twins (100-60) became Major League Baseball's fourth team to eclipse the century mark -- the first time in MLB history with a quartet of 100-win ballclubs, joining the Astros, Yankees and the Los Angeles Dodgers (104-56) -- after Friday's 6-2 win over the Kansas City Royals.
The matchup means a home run derby might be about to get underway.
Both sides have been atop the league in home runs, trading places throughout the year while the Yankees (305) lead the Twins (303) with two regular-season games to go.
The long balls were on full display when the teams faced off during the 2019 campaign, with the Yankees taking the head-to-head series 4-2 and winning both three-game sets May 3-5 and July 22-24.
In those games, the Twins and Yankees totaled 26 home runs, with Minnesota claiming the 16-12 edge over New York.
Perhaps the best example of the firepower from both teams was July 23's instant classic.
Of the 30 hits tallied by both sides during the Yankees' 14-12 win in 10 innings, six were homers, including four from the Twins.
Twenty of the 26 home runs came at Target Field, where the Twins will host Games 3 and 4 (if necessary) on Oct. 7 and 8.
After Game 1, the Yankees take the Twins on next Saturday at Yankee Stadium, which if necessary will host Game 5 on Oct. 10.
In the past, the Yankees have owned the Twins when the calendar has flipped to October, taking 13 of 15 games and including four ALDS matchups -- 2003, '04, '09 and '10.
Two years ago, the Yankees won the 2017 AL Wild Card Game, coming back from down three runs early and surging into an eventual ALCS run after the 8-4 victory against the Twins.