UConn watched their slim lead evaporate in the second quarter and wound up losing by 30 points in a 49-19 mess on Saturday night.
UConn's defense prevented any touchdowns in the first quarter and the team held a 13-7 advantage in the second quarter, but then Tulsa scored seven touhdowns in seven drives and ran away with the win.
Tulsa QB Seth Boomer threw four touchdowns to help lead his team to victory.
The loss on Saturday marked the sixth time this season that UConn lost by at least 30 points.